Table 4 Upstream regulators identified from intersection between public data and NGS experimental data under PM exposure. Bold texts indicate the hub genes consonant with Fig. 5.

From: Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter

Upstream regulator

Activation z-score

p-value of overlap

Target molecules in dataset

TNF

2.403

1.96E−14

CXCL1, GBP1, IL6, MMP1, MMP9, PLAU, S100A8, S100A9, SERPINB2

CD36

2.236

7.12E−12

CXCL1, IL6, MMP1, PLAU, SERPINB2

NFkB (complex)

2.376

5.32E−10

CXCL1, IL6, MMP1, MMP9, PLAU, SERPINB2

ERK

2.219

7.98E−10

CXCL1, IL6, MMP1, MMP9, SERPINB2

IL1B

2.188

6.52E−08

CXCL1, IL6, MMP1, MMP9, SERPINB2

TP53

− 1.913

0.00024

EGR1, IL6, MMP9, SERPINE1

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