Table 3 Top five IPA enriched canonical pathways of differentially expressed genes in the amygdala and PVN of emulsifier treated mice.
Top canonical pathways | ||
|---|---|---|
Name | p-value | Overlap |
Amygdala—CMC vs water | ||
MIF regulation of innate immunity | 9.47E−05 | 7.1% 3/42 |
Corticotropin releasing hormone signaling | 2.45E−04 | 2.8% 4/145 |
Coronavirus pathogenesis pathway | 2.79E−04 | 2.7% 4/150 |
CD40 signaling | 3.48E−04 | 4.6% 3/65 |
ILK signaling | 6.81E−04 | 2.1% 4/190 |
Amygdala—P80 vs water | ||
IL-17A signaling in gastric cells | 1.08E−03 | 8.7% 2/23 |
T cell receptor signaling | 1.39E−03 | 2.9% 3/104 |
CD28 signaling in T helper cells | 1.67E−03 | 2.7% 3/111 |
TNFR2 signaling | 1.84E−03 | 6.7% 2/30 |
IL-17A signaling in fibroblasts | 2.22E−03 | 6.1% 2/33 |
PVN—CMC vs water | ||
Opioid signaling pathway | 4.14E−06 | 3.8% 9/236 |
G-Protein coupled receptor signaling | 8.10E−05 | 3.0% 8/267 |
Corticotropin releasing hormone signaling | 9.13E−05 | 4.3% 6/139 |
CREB signaling in neurons | 1.95E−04 | 1.9% 11/570 |
CDK5 signaling | 2.19E−04 | 4.8% 5/104 |
PVN—P80 vs water | ||
Role of JAK2 in hormone-like cytokine signaling | 6.22E−04 | 9.4% 3/32 |
Opioid signaling pathway | 1.52E−03 | 2.5% 6/236 |
Role of Wnt/GSK-3 signaling in the pathogenesis of influenza | 4.63E−03 | 4.7% 3/64 |
Human embryonic stem cell pluripotency | 5.02E−03 | 3.1% 4/131 |
Role of JAK1 and JAK3 in c cytokine signaling | 5.49E-03 | 4.4% 3/68 |
