Figure 2 | Scientific Reports

Figure 2

From: mGluR5 ablation leads to age-related synaptic plasticity impairments and does not improve Huntington’s disease phenotype

Figure 2The alternative text for this image may have been generated using AI.

Lack of mGluR5 decreases dendritic spine density and maturation in the hippocampus of aged mice. (A) Colored graph shows the contribution of each type of spine per 20 µm of dendrite segment in the hippocampus of wild-type (WT), BACHD, mGluR5−/− and BACHD/mGluR5−/− mice at 12 months of age (n = 10–12). (B) Shown are representative confocal micrographs from tertiary dendrites of hippocampal neurons from wild-type (WT), BACHD, mGluR5−/− and BACHD/mGluR5−/− mice at 12 months of age. Dendrite segments shown are 20 µm in length and size bar corresponds to 5 µm. Graphs show total number of dendritic spines (C) and the number of mature mushroom (D) and transient long (E) spines per 20 µm of dendrite segment. Data represent the means ± SEM. *p < 0.05 by one-way ANOVA and Bonferroni's multiple comparisons test.

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