Table 1 List of 23 Key metabolites obtained from t-test responsible for discriminating sea level control group and Siachen group.

From: Urinary metabolic modulation in human participants residing in Siachen: a 1H NMR metabolomics approach

Metabolites name

Metabolite's concentration

Univariate analysis

Multivariate analysis

Pathway

Area of metabolite's NMR peaks/area of NMR peak of 0.1 mM TSP (mean ± Std)

Baseline

Siachen

t-value

p value

− log10(p)

FDR

PLS-DA

OPLS-DA

Random forest

HMDB

Sea-level

(Altitude: 3700 m)

VIP scores

MDA

Cisaconitate

0.0544 ± 0.0150

0.3924 ± 0.0840

− 14.5560

0.0000

26.2080

0.0000

2.1597

2.0918

0.0490

HMDB0000072

NMN

0.0154 ± 0.0070

0.0456 ± 0.0088

− 12.5440

0.0000

21.8800

0.0000

1.8782

1.9151

0.1353

HMDB0000229

Tyrosine

0.3516 ± 0.1290

0.6681 ± 0.0909

− 9.4024

0.0000

14.8720

0.0000

1.7805

1.8007

0.0160

HMDB0000158

Choline

0.4881 ± 0.1544

0.7811 ± 0.0726

− 9.1794

0.0000

14.3720

0.0000

1.7560

1.8501

0.0266

HMDB0000097

Creatinine

5.0116 ± 1.6229

5.0499 ± 0.5427

7.6818

0.0000

11.0630

0.0000

1.5431

1.6007

0.0207

HMDB0000562

Isoleucine

0.4176 ± 0.1330

0.7659 ± 0.1244

− 7.5397

0.0000

10.7550

0.0000

1.5348

1.6129

0.0055

HMDB0000172

Alanine

0.2098 ± 0.0725

0.3218 ± 0.0319

− 6.6677

0.0000

8.9054

0.0000

1.4138

1.4630

0.0111

HMDB0000161

Cysteine

0.3519 ± 0.1147

0.3355 ± 0.0326

6.2969

0.0000

8.1432

0.0000

1.4294

1.3883

0.0075

HMDB0000574

Dihydroxymandalate

0.0556 ± 0.0189

0.0852 ± 0.0079

− 5.8819

0.0000

7.3118

0.0000

1.3182

1.3309

0.0033

HMDB0001866

Allantoin

0.0156 ± 0.0070

0.0298 ± 0.0035

− 4.9027

0.0000

5.4609

0.0000

1.2858

1.2422

0.0078

HMDB0000462

Acetoacetate

0.1341 ± 0.0485

0.1833 ± 0.0205

− 4.0759

0.0001

4.0491

0.0003

1.0650

1.0521

0.0107

HMDB0000060

Lactate

0.2661 ± 0.0863

0.3991 ± 0.0408

− 3.8325

0.0002

3.6647

0.0006

1.0761

1.0328

0.0180

HMDB0000190

Sarcosine

0.1906 ± 0.0617

0.2537 ± 0.0256

− 3.5301

0.0006

3.2089

0.0016

0.8341

0.8670

0.0028

HMDB0000271

TMAO

0.5334 ± 0.1812

0.5278 ± 0.0723

3.5292

0.0006

3.2076

0.0016

0.8007

0.7650

0.0028

HMDB0000925

Succinate

0.0428 ± 0.0131

0.0488 ± 0.0050

3.4421

0.0008

3.0809

0.0020

0.8418

0.8165

 

HMDB0000254

Indoxylsulphate

0.0338 ± 0.0152

0.0266 ± 0.0064

3.1382

0.0022

2.6563

0.0050

 

Methylhistidine

0.0052 ± 0.0031

0.0040 ± 0.0013

2.8163

0.0058

2.2363

0.0123

Dimethylamine

0.2874 ± 0.0879

0.3299 ± 0.0344

2.6066

0.0105

1.9799

0.0209

Glycine

0.3636 ± 0.1567

0.5094 ± 0.0610

− 2.5009

0.0139

1.8560

0.0264

Acetate

0.1145 ± 0.0455

0.1129 ± 0.0122

2.4159

0.0174

1.7589

0.0314

Dimethylglycine

0.0921 ± 0.0309

0.1209 ± 0.0138

− 2.3599

0.0201

1.6962

0.0345

Hydroxybutyrate

0.3158 ± 0.1073

0.3937 ± 0.0486

− 2.2830

0.0244

1.6118

0.0400

Urocanate

0.0281 ± 0.0234

0.0166 ± 0.0180

2.2182

0.0287

1.5422

0.0449

  1. p values were derived from two-tailed Student’s t test. FDR values were calculated which indicates false discovery rates.
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