Table 1 Characteristics of included studies.

Dere

2020

Turkey

PV

30

30

DRB1*01, *03, *04, *07, *08, *11, *12, *13, *14, *15, DQB1*02, *03, *04, *05, *06

PCR-SSP

Genotype frequency

⁸⁰

Ehsan

2015

Iran

MuSK MG

24

200

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *1301, *1302, *1303, *14, *15, *16,

DQB1*0201, *0301, *0302, *0303, *05, *0601, *0602, *0603, *0604

DRB1*14-DQA1*0104, DQB1*05, DRB1*15-DQA1*0102-DQB1*0601, DRB1*15-DQA1*0102-DQB1*0602, DRB1*15-DQA1*0103-DQB1*0601, DRB1*16-DQA1*0102-DQB1*05

PCR-SSP

Allele frequency, haplotype frequency

⁸¹

Alahgholi-Hajibehzad

2013

Turkey

MuSK MG

48

250

DRB1*03, DRB1*14, DRB1*16, DQB1*05

DRB1*14-DQB1*05, DRB1*16-DQB1*05

PCR-SSP

Genotype frequency, haplotype frequency

⁸²

Harfouch

2014

Syria

PV

91

270

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

PCR-SSP

Genotype frequency

⁸³

Gonzalez-Escribano

1998

Spain

PV

26

200

DR1, DR2, DR3, DR4, DR7, DR8, DR9, DR10, DR11, DR12, DR13, DR14

PCR-SSOP, PCR-SSP

Genotype frequency

⁸⁴

Brochado

2016

Brazil

PF

86 (172)

1592 (3184)

DRB1*01:01, DRB1*01:02, DRB1*04:02, DRB1*07:01, DRB1*08:04, DRB1*11:01, DRB1*13:01, DRB1*14:01, DRB1*14:04

DQB1*03:01, *03:02, *05:01, *05:03, *06:02, *06:03

DRB1*14-DQA1*01-DQB1*05, DRB1*16-DQA1*01-DQB1*05

Commercial kits form One Lambda

Allele frequency, haplotype frequency

⁸⁵

PV

82 (164)

1592 (3184)

DRB1*01:01, *01:02, *04:02, *07:01, *08:04, *11:01, *13:01, *14:01, *14:04

DQB1*03:01, *03:02, *05:01, *05:03, *06:02, *06:03

DRB1*15-DQA1*01-DQB1*06, DRB1*14-DQA1*01-DQB1*05, DRB1*16-DQA1*01-DQB1*05

Martel

2002

France

PF

31

84

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16,

PCR-SSO, PCR-SSP, PCR–RFLP

Genotype frequency

⁸⁶

30

64

DQB1*02, *03:02, *05:03

Párnická

2013

Slovakia

PV

43 (86)

113 (226)

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

DRB1*14-DQB1*05:03, DRB1*14:54-DQB1*05:03, DRB1*14:04-DQB1*05:03, DRB1*14:05-DQB1*05:03

PCR-SSP

Allele frequency, haplotype frequency

⁸⁷

Nikolic

2014

Serbia

MuSK MG

31 (62)

1992 (3984)

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

PCR with sequence-specific oligonucleotides

Genotype frequency, allele frequency, haplotype frequency

⁷⁸

31 (62)

159 (318)

DQB1*02, *03, *04, *05, *06

DRB1*14-DQB1*05, DRB1*16-DQB1*05, DRB1*15-DQB1*06

De Sena Nogueira Maehara

2017

Brazil

Fogo selvagem

42 (84)

478 (956)

DRB1*02, *04, *05, *07, *16

PCR-SSO

Allele frequency

⁸⁸

Netherlands

PF

17 (34)

447 (894)

DRB1*04

Coppo

2010

France

TTP

61

172

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

PCR-SSO

Genotype frequency

⁸⁹

60

172

DQB1*02, *03, *04, *05, *06

Kanai

2016

Japan

MuSK MG

14

100

DRB1*01, *04, *08, *09, *11, *12, *13, *14, *15, 16

DQB1*03, *04, *05, *06

PCR-SSP

Genotype frequency, haplotype frequency

⁹⁰

Piccinelli

2019

Italy

CIDP

24 (48)

216 (432)

DRB1*01, *03, *04, *07, *08, *10, *11, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

DRB1*15-DQB1*06

PCR-SSP

Allele frequency, haplotype frequency

⁹¹

Zivanovic

2016

Serbia

PV

72 (144)

1992 (3984)

DRB1*01, *03, *04, *07, *11, *12, *13, *14, *15, *16

PCR-SSP

Allele frequency, haplotype frequency

⁷⁹

72 (144)

159 (318)

DQB1*02, *03, *04, *05, *06

DRB1*14-DQB1*05, DRB1*16-DQB1*05, DRB1*15-DQB1*06

Saha

2019

UK

PF (Caucasian white British)

25 (50)

100 (200)

DRB1*01, *04, *14

DQB1*0302, *0501, *0502, *0503

PCR-SSP

Allele frequency

⁹²

PF (Indo-Asians)

10 (20)

59 (118)

DRB1*01, *04, *14

DQB1*0302, *0501, *0503

Gil

2017

Brazil

PV

102

594

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

PCR-SSP

Genotype frequency

⁹³

Torzecka

2003

Poland

PF

15 (30)

152 (304)

DRB1*01, *03, *04, *07, *08, *09, *10 *11, *12, *13, *14, *15

Dynal RELI SSO HLA-DRB Test

Allele frequency

⁷⁴

PV

38 (76)

152 (304)

DRB1*01, *03, *04, *07, *08, *09, *10 *11, *12, *13, *14, *15

Abida

2009

Tunisia

PF

90 (180)

270 (540)

DRB1*03, *04, *11, *13, *15

DQB1*0301, *0302, *06

PCR-SSP

Allele frequency

⁹⁴

Ogata

2020

Japan

CIDP

22 (44)

418 (836)

DRB1*01, *03, *04, *08, *09, *10, *11, *12, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

DRB1*14:05-DQB1*05:03, DRB1*15:01-DQB1*06:02, DRB1*15:02-DQB1*06:01

Next-generation sequencing

Allele frequency, haplotype frequency

⁹⁵

Priyadarshini

2018

India

PV

50

50

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

DRB1*14-DQB1*05, DRB1*15-DQB1*06

PCR-SSOP

Genotype frequency, haplotype frequency

⁹⁶

Tunca

2010

Turkey

PV

25

113

DRB1*01, *03, *04, *05, *06, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

PCR-SSP

Genotype frequency

⁹⁷

Haase

2015

Germany

PV (German)

46 (92)

74 (148)

DRB1*01, *02, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

PCR-SSP

Allele frequency

⁹⁸

PV (Egypt)

47 (94)

73 (146)

Martinez-Martinez

2017

Spain

CIDP

13

941

DRB1*15

DNA sequence analysis and SSP methodology

Genotype frequency, Haplotype frequency

⁹⁹

13

35

DRB1*15-DQB1*06

Glorio

1999

Argentina

PV

30

199

DR3, DR4, DR8, DR14, DR15

DQB1*03, *05

PCR-SSO

Genotype frequency

¹⁰⁰

Pavoni

2003

Brazil

Fogo selvagem

128

402

DRB1*01, *03, *04, 07, *08, *09, *10, *11, *12, *13, *14, *15, *16

PCR-SSOP

Genotype frequency

¹⁰¹

Thomas

1998

Spain

PV

26

200

DR1, DR2, DR3, DR4, DR7, DR8, DR9, DR10, DR11, DR12, DR13, DR14

PCR-SSOP, PCR-SSP

Genotype frequency

¹⁰²

Zhang

2019

China

PF

72

501

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

Affymetrix axiom precision medicine research array based GWAS

Genotype frequency, allele frequency

⁷⁵

PV

255

501

Moraes

1991

Brazil

Fogo selvagem

37

49

DR1, DR16, DQ2

PCR-SSP

Genotype frequency

¹⁰³

38

46

DRB1*15

38

41

DQB1*06

Lee

1998

South Korea

PF

15

100

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

PCR-SSP

Genotype frequency

⁷⁶

PV

15

100

Shams

2008

Iran

PV

52 (104)

180 (360)

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

DRB1*15-DQA1*01-DQB1*06

DRB1*16-DQA1*01, DQB1*05

PCR-SSP

Allele frequency, haplotype frequency

¹⁰⁴

Orouji

2014

Mid-east origin

PV

54

85

DQB1*02, *03, *04, *05, *06

PCR-SSP

Genotype frequency, allele frequency

¹⁰⁵

Miyagawa

1997

Japan

PF

9

525

DRB1*04, *14

DQB1*03, *05

DRB1*14-DQA1*01-DQB1*05

NA

Genotype frequency, haplotype frequency

⁷⁷

PV

7

525

Joly †

2020

France

TTP

26

172

DRB1*04, *11

DQB1*03

PCR-SSP

Genotype frequency, allele frequency

¹⁰⁶

Glorio

2002

Argentina

PV

47

199

DR3, DR4, DR8, DR14, DR15

DQB1*03, *05

PCR-SSO

Genotype frequency

¹⁰⁷

Sakai

2020

Japan

TTP

52 (104)

523 (1046)

DRB1*01, *04, *08, *09, *11, *12, *13, *14, *15

DQB1*03, *04, *05, *06

Commercial kits with Illumina MiSeq technology

Allele frequency

¹⁰⁸

Koc

2012

Turkey

Pemphigus

60

60

DRB1*04, *11, *14

DQB1*02, *05, *06

PCR-SSP

Genotype frequency

¹⁰⁹

Scully

2010

UK

TTP

50

200

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

PCR-SSP, PCR-SSOP

Genotype frequency

¹¹⁰

Mobini

1997

Iran

PV

38

57

DRB1*14-DRB3*02-DQB1*05-DQA1*01,

DRB1*15-DRB5*01-DQB1*06-DQA1*01,

DRB1*15-DRB5*01-DQB1*06-DQA1*05

PCR-SSOP

Haplotype frequency

¹¹¹

Delgado

1997

Pakistan

PV (Pakistan)

19 (38)

13 (26)

DRB1*01, *02, *03, *04, *07, *10, *11, *13, *14

DQB1*02, *03, *04, *05, *06

PCR-SSOP

Allele frequency

¹¹²

Europe

PV (Europe)

19 (38)

248 (496)

DRB1*01, *02, *04, *07, *08, *11, *12, *13, *14

DQB1*02, *03, *05, *06

Yamashina

1998

Japan

PV

17

525

DRB1*04, *14

DQB1*03, *05

PCR–RFLP

Genotype frequency, haplotype frequency

¹¹³

Al Haddad

2019

Lebanon

TTP

30

30

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

PCR-SSP

Genotype frequency

¹¹⁴

John

2011

Germany

TTP

54

11,407

DRB1*01, *03, *04, *07, *08 *09, *11, *12, *13, *14

PCR-SSP, PCR-SSO

Genotype frequency

¹¹⁵

50

174

DQB1*02

54

174

DQB1*04, *05

47

174

DQB1*03

52

174

DQB1*06

Martino

2016

France

TTP

26 (52)

663 (1326)

DRB1*04, DRB1*11

PCR-SSO

Allele frequency

¹¹⁶

26 (52)

437 (874)

DQB1*03

24 (48)

100 (200)

DRB1*04, DRB1*11

DQB1*03

Cerna

1993

Brazil

Fogo selvagem

10

74

DRB1*04, *08, *14, *16

DQB1*03, *04

PCR-SSOP

Genotype frequency

¹¹⁷

Birol

2002

Turkey

Pemphigus

33

100

DR4, DR11, DR14

DQ2, DQ4

Microdroplet lymphocyte test

Genotype frequency

¹¹⁸

Rangel-Gamboa

2015

Mexico

PV

43 (86)

99 (198)

DR1, DR4, DR7, DR8, DR11, DR13, DR14, DR16

PCR-SSO

Allele frequency

¹¹⁹

Khan

2015

Pakistan

PV

28

150

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

PCR-SSP

Genotype frequency

¹²⁰

Carcassi

1996

Italy

PV (Sardinians)

16 (32)

91 (182)

DRB1*03, *04, *08, *14

DQB1*02, *03, *05

PCR-SSO

Allele frequency

¹²¹

PV (Italians)

16 (32)

284 (568)

DRB1*03, *04, *08, *14

16 (32)

406 (812)

DQB1*02, *03, *05

Lombardi

1996

Italy

PV

33

102

DRB1*01, *03, *04, *07, *08, *11, *13, *14, *15, *16

DQB1*02, *03, *04, *05, *06

PCR-SSO

Genotype frequency

¹²²

Saha

2010

UK

PV (white Europeans)

96 (192)

100 (200)

DRB1*03, *04, *07, *14, *15

DQB1*02, *03, *05, *06

PCR-SSP

Allele frequency

¹²³

PV (Indo-Asians)

57 (114)

59 (118)

Niks

2006

Netherlands

MuSK MG

23

2440

DR1, DR3, DR14, DR16, DQ5, DQ6

PCR-amplified fragments and biotin labelled oligonucleotides

Genotype frequency, Haplotype frequency

¹²⁴

23 (46)

321 (642)

DRB1*14-DQB1*05, DRB1*15-DQB1*05

Sinkovits

2017

Hungary

TTP

75

204

DRB1*01, *03, *04, *07, *08, *09, *10, *11, *12, *13, *14, *15, *16

PCR-SSO

Genotype frequency, Haplotype frequency

¹²⁵

75

162

DRB1*14-DQB1*05, DRB1*16-DQB1*05, DRB1*15-DQB1*06