Figure 5 | Scientific Reports

Figure 5

From: Signaling events evoked by domain III of envelop glycoprotein of tick-borne encephalitis virus and West Nile virus in human brain microvascular endothelial cells

Figure 5The alternative text for this image may have been generated using AI.

Differential expression of the genes in HBMECs challenged with rDIII-TBEV and rDIII-WNV. Heat maps presenting deregulation of gene expression involved the vesicle-mediated transport (mainly clathrin-mediated endocytosis and Rab regulation of trafficking). * Indicates genes involved in Rab regulation of trafficking. Attachment of rDIII on HBMECs also evoked expression of several genes related to apoptosis. The intensity of the color indicates the degree of expression level (logFC), presented in the scale. Gene expression was considered as significant only when the LogFC was beyond ± 1.2, average logCPM (count per million) was > 3, and p-value was < 0.01. An edgeR package was used for statistical analysis of differentially expressed gene. The unshrunk.logFC and false discovery rate (FDR) values for each genes are presented in Supplementary Dataset.

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