Table 3 Pooled, and stratified by received respiratory support 12-month outcomes.

From: “Long COVID” results after hospitalization for SARS-CoV-2 infection

 

Pooled

Stratified

OR (95% CI), p-value

aOR# (95% CI), p-value

N (%)

No supplemental oxygen or low-flow oxygen, n (%)

HFNC or NIV or IMV, n (%)

 

344

276

68

  

Outcomes

Symptoms

87/344 (25.3)

57 (20.6)

30 (44.1)

3.03 (1.73–5.31), < 0.01

3.66 (1.73–7.74), < 0.01

Dyspnea

42/345 (12.2)

29 (10.5)

13 (18.8)

1.98 (0.97–4.04), 0.06

1.87 (0.73–4.76), 0.19

mMRC scale 0

303 (87.8)

247 (89.5)

56 (81.1)

*1.98 (0.97–4.04), 0.06

*1.87 (0.73–4.76), 0.19

mMRC scale 1

32 (9.3)

23 (8.3)

9 (13.0)

mMRC scale 2

6 (1.7)

4 (1.5)

2 (2.9)

mMRC scale 3

3 (0.9)

2 (0.7)

1 (1.5)

mMRC scale 4

1 (0.3)

0 (0.0)

1 (1.5)

Neurological symptoms

35/345 (10.1)

15 (5.4)

20 (29.0)

7.10 (3.40–14.82), < 0.01

8.96 (3.22–24.90), < 0.01

COVID-related re-hospitalization

5/377 (1.3)

5/302 (1.7)

0/75 (0.0), (p§ = 0.59)

Not performable

Not performable

Overall 12-month mortality

94/471 (20.0)

79/381 (20.7)

15/90 (16.7)

0.76 (0.42–1.40), 0.39

0.54 (0.24–1.20), 0.13

IgG

192/224 (85.7)

137/161 (85.6)

55/62 (85.9)

1.03 (0.45–2.36), 0.95

1.82 (0.56–5.87), 0.32

Vaccinated

132/322 (41.0)

    

Walking test 0

7/11 (63.6)

6 (75.0)

1 (33.3)

*6.00 (0.33–107.42), 0.22

Not performable

Walking test 1

4/11 (36.4)

2 (25.0)

2 (66.7)

Walking test 2

0/11 (0.0)

0 (0.0)

0 (0.0)

Parenchymal CT 0, 1, 2 (normal or mild damage)

46/47 (97.9)

12 (100.0)

34 (97.1)

Not performable

Not performable

Parenchymal CT 3, 4 (moderate to severe damage)

1/47 (2.1)

0 (0.0)

1 (2.9), (p§ = 1.00)

Interstitial CT 0, 1, 2 (normal or mild damage)

10/47 (21.3)

4 (33.3)

6 (17.1)

2.42 (0.55–10.70), 0.25

0.83 (0.07–9.15), 0.88

Interstitial CT 3, 4 (moderate to severe damage)

37/47 (78.7)

8 (66.7)

29 (82.9), 0.25

  1. CT  computed tomography, HFNC  high-flow nasal cannula, IgG  immunoglobulin G, IMV  invasive mechanical ventilation, mMRC  Modified Medical Research Council, NIV  non-invasive mechanical ventilation, TC  computed tomography.
  2. *For every 1 point increase.
  3. #Adjusted for gender, age, obesity, and NEWS2 (National Early Warning Score 2) at admission.
  4. §Fischer exact test.