Figure 3
From: Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function
Changes in residual flexibilities during simulation. (A) Changes are represented by root mean square fluctuation (RMSF) plots for W50S (a), R52C (b), and D104G (c) versus the wild-type structure. Color bars represents β-sheet propensity and CDRs. (B) Comparison of TREM2 Ig domain fluctuations as demonstrated by B-factor coloring and thickness. RMSF values were converted to B-factors to represent structures in colored putty representations . Coloring was made by white-red spectrum, white means B-factor with a value 0, while red means 300. Tube thicknesses also indicate levels of fluctuation, i.e., tube thicknesses represent levels of fluctuation.
