Figure 4
From: Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function
Alterations in the correlated motions in TREM2 variants. (A) The dynamic cross-correlation matrix (DCCM) plot shows anticorrelated and correlated motions between every two residues in the structure. Here a perfect correlated motion is denoted by red (+ 1), and an anticorrelated motion by blue (− 1). CDRs are indicated by dotted boxes. (B) DCCM representation in the structural view of TREM2, where lines denote correlations between two residues. A blue line indicates anticorrelated motions, and a red line denotes positive correlations. Color intensities indicate strengths of correlations.
