Table 2 Higher combinatory mRNA expressions of all ten hub genes were associated with clinical characteristic in HCC.
Characteristic | N | Low expression of hub genes | High expression of hub genes | Hazard ratio | P value |
|---|---|---|---|---|---|
Gender | |||||
Male | 246 | 84 | 162 | 0.35 (0.22–0.55) | 1.40E − 06 |
Female | 118 | 74 | 44 | 0.66 (0.37–1.20) | 0.17 |
Race | |||||
White | 181 | 121 | 60 | 0.69 (0.42–1.12) | 0.13 |
Asian | 155 | 83 | 72 | 0.17 (0.08–0.38) | 1.10E − 06 |
Alcohol consumption | |||||
Yes | 115 | 46 | 69 | 0.54 (0.29–1.02) | 0.053 |
No | 202 | 112 | 90 | 0.40 (0.24–0.66) | 0.00023 |
Hepatitis virus | |||||
Yes | 150 | 79 | 71 | 0.29 (0.14–0.62) | 0.00068 |
No | 167 | 113 | 54 | 0.54 (0.32–0.89) | 0.015 |
Stage | |||||
1 + 2 | 253 | 126 | 127 | 0.43 (0.26–0.71) | 0.00067 |
3 + 4 | 87 | 25 | 62 | 0.37 (0.20–0.67) | 0.00064 |
Grade | |||||
1 | 55 | 34 | 21 | 0.40 (0.14–1.16) | 0.082 |
2 | 174 | 55 | 119 | 0.42 (0.25–0.71) | 0.00078 |
3 | 118 | 72 | 46 | 0.25 (0.12–0.55) | 0.00018 |
4 | 12 | – | – | – | – |
AJCC_T | |||||
1 | 180 | 62 | 118 | 0.42 (0.23–0.75) | 0.0024 |
2 | 90 | 35 | 55 | 0.51 (0.25–1.05) | 0.062 |
3 | 78 | 23 | 55 | 0.33 (0.17–0.62) | 0.00034 |
4 | 13 | – | – | – | – |
Vascular invasion | |||||
No | 203 | 68 | 135 | 0.47 (0.28–0.79) | 0.0035 |
Micro | 90 | 28 | 62 | 0.42 (0.19–0.91) | 0.023 |
Macro | 16 | – | – | 0.33 (0.17–0.62) | – |
