Figure 4
(A) Bacteria significantly enriched in males, subsetted to the 50 bacteria with the strongest association. Examples of bacteria with distinct inheritance patterns are highlighted in yellow and blue and shown in D–E. (B) Bacteria that were found to be significantly enriched in females (purple). (C) Boxplot of correlations between children and parents of different sexes, as measured by the \(R^2\) metric of log-normalized counts. (D) Example of a bacteria with inheritance patterns illustrative of y-chromosome repeats mismapping to bacterial contigs. (E) Example of a less clear inheritance pattern, which we hypothesize results from a sequence present both on the X and Y chromosome in varying numbers of repeats. (F) A sub-sampled volcano plot for the association between counts of 100-mers extracted from reads mapping to sex-associated bacteria and sex, using a paired analysis of siblings. The red line represents the Bonferonni-adjusted p-value cutoff, with statistically significant hits in orange.
