Table 3 Results of linear regression of structural retinal parameters and white matter lesions volume ratio index in patients with cerebral small vessel disease.

Structural retinal parameter	WMRI association		WMRI association, age adjusted
Structural retinal parameter	β [95%-CI]	p	β [95%-CI]	p
IPL
Pf. nasal	− 45.261 [− 86.436, − 4.085]	0.033	− 27.364 [− 61.017, 6.289]	0.106
Pf. inferior	− 31.918 [− 59.769, − 4.068]	0.026	− 21.373 [− 43.621, 0.874]	0.059
OPL
Foveal	137.950 [62.956, 212.944]	0.001	101.841 [40.874, 162.808]	0.002
pRNFL
Temporal	− 0.032 [− 0.060, − 0.005]	0.024	− 0.029 [− 0.049, − 0.009]	0.007
PMB	− 0.038 [− 0.075, − 0.001]	0.042	− 0.039 [− 0.064, − 0.013]	0.005
MRW
Nasal	− 0.003 [− 0.007, 0.000]	0.044	− 0.002 [− 0.005, 0.001]	0.234
Nasal inferior	− 0.004 [− 0.007, 0.000]	0.030	− 0.003 [− 0.005, 0.000]	0.024
Temporal inferior	− 0.004 [− 0.008, − 0.001]	0.017	− 0.003 [− 0.006, − 0.001]	0.016
PMB	− 0.004 [− 0.007, 0.000]	0.033	− 0.002 [− 0.005, 0.001]	0.209
Nasal superior	− 0.004 [− 0.007, − 0.001]	0.018	− 0.002 [− 0.005, 0.000]	0.087

Associations between retinal parameters and WMRI were assessed using linear regression. Model 1: univariate regression, Model 2: multivariable regression adjusted for age. Significant associations (p < 0.05) are displayed in bold.
In this table, only parameters are listed with a p value < 0.05 in at least one linear regression model. Further results are listed in the supplement. The volumes of the macular layers correspond to the foveal and parafoveal volumes (3-mm-circle).
WMRI, white matter lesions volume ratio index; β, standardized coefficient; CI, confidence interval; IPL, inner plexiform layer; pf., parafoveal; OPL, outer plexiform layer; pRNFL, peripapillary retinal nerve fiber layer; PMB, papillo-macular bundle; MRW, Bruch’s membrane opening-minimum rim width.

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