Figure 5
From: Metagenomic assembled plasmids of the human microbiome vary across disease cohorts
Intra-sample plasmidome differences are associated with IBD. (a) Shannon index α-diversity comparisons, and (b) β-diversity PCoA ordination of Canberra distances, of control, CD, and UC plasmidomes. The shape aesthetic indicates the recorded severity of patients with IBD, with the number of samples analysed per cohort displayed in brackets within the legend. (c) Wilcoxon signed-rank test with Bonferroni-correction to assess statistical significance of plasmidome α-diversity differences between non-IBD controls and patients with IBD grouped by disease severity. (d) Proportional Venn diagram of human plasmidome database plasmids detected across the total control, CD, and UC cohorts. The majority of plasmids are detected within all three cohorts (508 of 873 plasmids), with only 18 and 29 plasmids unique to CD and UC, respectively. (e) Scatter plot of plasmid richness compared to the overall total microbiome sample richness. The shape aesthetic highlights the reported severity of patients with IBD, with the shading around the linear model regression line representing a 0.95 confidence interval.
