Figure 3
HCT 116 cells cocultured with SciNPs. (a) 3D reconstructed MAXWELL image. (b) image of the same sample taken with UV irradiation. Note that the color was presented from the 3D visualization process and does not represent the emission color of the SciNPs. (c) MAXWELL image of HCT 116 cells loaded with SciNPs. The z-direction has a scale 5 times larger than the xy-directions to show the 3D structure of the SciNPs. Note that particles appear distributed in the same plane because the cultured cells spread on the glass substrate, their distribution becoming very thin in the z-direction. (d) TEM images of an HCT 116 cell revealing that many NaGdF4:Eu (left) and NaGdF4:Tb (right) nanoparticles were internalized in the cytoplasm. The cell nuclei are marked by asterisks. Scale bars: (a,b) 50 µm; (c) 10 µm; (d) 5 µm.
