Figure 5
(a,b) MAXWELL images of mouse brain perfused with SciNPs (NaGdF4:Eu) to delineate the microvessels induced by tumor angiogenesis. SciNPs found outside the blood vessels, such as those marked by yellow arrows and circles, are attributed to the leakage through the fenestrations on the angiogenic microvessel walls. Red arrows mark microvessels with diameter ≤ 10 µm. (c) A micrograph obtained with UV illumination shows the red light emission of SciNPs aggregated in the microvessels. (d) Low-magnification MAXWELL images showing the aggregation of SciNPs in a region of a mouse brain. Inset: the entire brain imaged after tissue clearing. Scale bars: (a) 10 µm; (b,c) 50 µm; (d) 1 mm; inset: 5 mm.
