Figure 1 | Scientific Reports

Figure 1

From: Exploration of serum biomarkers in dogs with malignant melanoma receiving anti-PD-L1 therapy and potential of COX-2 inhibition for combination therapy

Figure 1

Serum concentrations of several immune modulators are elevated in dogs with pulmonary metastatic oral malignant melanoma (OMM). (a) Heat map depicting the serum concentrations of each measured factor (as Z-Scores) in dogs with OMM prior to treatment (n = 27) and in healthy dogs (n = 8). Missing values (below the lower limit of quantitation [LLOQ]) are shown in dark green. (b) Comparison of serum concentration between OMM and healthy dogs. Red bars indicate the median values. Values below LLOQ are shown as open circles. Statistical analysis was performed using Mann–Whitney U test.

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