Table 1 ROC analysis of each serum factor in relation to longer survival.

From: Exploration of serum biomarkers in dogs with malignant melanoma receiving anti-PD-L1 therapy and potential of COX-2 inhibition for combination therapy

 

AUC (95% CI)

Cutoff*

Sensitivity

Specificity

P value**

PGE2

0.727 (0.501–0.954)

6.5

0.636

0.846

0.033

IFN-γ

0.566 (0.416–0.717)

< LLOQ

0.231

0.909

0.596

IL-2

0.626 (0.398–0.854)

17.7

0.545

0.769

0.206

IL-6

0.535 (0.299–0.771)

142.4

0.364

1.000

0.031

IL-10

0.622 (0.412–0.833)

18.4

0.455

0.846

0.182

IL-12p40

0.587 (0.341–0.834)

388.5

1.000

0.308

0.098

TNF-α

0.521 (0.362–0.680)

4.7

0.182

0.923

0.576

IL-8

0.573 (0.329–0.818)

1980.8

0.727

0.538

0.240

MCP-1

0.664 (0.440–0.889)

48.7

0.273

1.000

0.082

NGF-β

0.521 (0.362–0.680)

28.0

0.182

0.923

0.576

SCF

0.741 (0.531–0.951)

87.7

0.727

0.692

0.100

VEGF-A

0.594 (0.353–0.835)

22.1

0.909

0.462

0.211

  1. The sensitivity and specificity of each factor to predict longer survival (OS > median) are shown.
  2. AUC, area under the curve; CI, confidence interval; LLOQ, lower limit of quantification.
  3. *Cutoffs were determined by calculating the Youden's index.
  4. **Fisher's exact test.
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