Table 2 ROC analysis of each serum factor in relation to tumor response.

From: Exploration of serum biomarkers in dogs with malignant melanoma receiving anti-PD-L1 therapy and potential of COX-2 inhibition for combination therapy

 

AUC (95% CI)

Cutoff*

Sensitivity

Specificity

P value**

PGE2

0.618 (0.285–0.951)

3.1

0.400

0.955

0.628

IFN-γ

0.614 (0.524–0.703)

< LLOQ

1.000

0.227

0.547

IL-2

0.818 (0.560–1.000)

33.0

0.800

0.864

0.030

IL-6

0.727 (0.414–1.000)

142.4

0.600

0.955

0.013

IL-10

0.691 (0.391–0.991)

84.6

0.400

1.000

0.136

IL-12p40

0.727 (0.470–0.985)

651.9

1.000

0.455

0.561

TNF-α

0.664 (0.407–0.920)

4.7

0.400

0.955

0.079

IL-8

0.618 (0.317–0.920)

2007.0

0.800

0.591

0.326

MCP-1

0.718 (0.524–0.913)

115.2

1.000

0.591

0.474

NGF-β

0.641 (0.380–0.902)

28.0

0.400

0.909

0.144

SCF

0.773 (0.520–1.000)

125.0

0.800

0.818

0.165

VEGF-A

0.500 (0.228–0.772)

17.9

0.600

0.636

1.000

  1. The sensitivity and specificity of each factor to predict tumor response are shown.
  2. AUC, area under the curve; CI, confidence interval; LLOQ, lower limit of quantification.
  3. *Cutoffs were determined by calculating the Youden's index.
  4. **Fisher's exact test.
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