Table 1 Effects of nobiletin or losartan on haemodynamic parameters in 2K-1C rats under anaesthesia.

From: Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats

Parameter

Sham

2K-1C

Vehicle

Vehicle

Nobiletin

15 mg/kg

Nobiletin

30 mg/kg

Losartan

10 mg/kg

SP (mmHg)

122 ± 3.97

195.89 ± 9.50a

178.24 ± 10.94a

131.21 ± 2.09b,c

124.20 ± 2.53b,c

DP (mmHg)

79.89 ± 4.42

130.98 ± 6.39a

99.61 ± 3.82b

85.68 ± 2.87b

83.10 ± 2 .57b

MAP (mmHg)

93.93 ± 4.20

152.61 ± 7.32a

125.52 ± 4.75a,b

100.52 ± 2.34b,c

96.80 ± 2.35b,c

PP (mmHg)

42.11 ± 1.73

64.91 ± 4.07a

79.08 ± 11.03a

44.54 ± 2.57b,c

41.10 ± 2.12b,c

HR (beats/min)

361.89 ± 16.53

425.53 ± 16.7a

415.48 ± 23.65

364.62 ± 19.15

352.96 ± 7.56b

  1. The data are expressed as the means ± SEMs.
  2. SP systolic blood pressure, DP diastolic blood pressure, MAP mean arterial pressure, PP pulse pressure, HR heart rate, 2K-1C two-kidney, one-clip.
  3. aP < 0.05 vs. sham.
  4. bP < 0.05 vs. 2K-1C.
  5. cP < 0.05 vs. 2K-1C + nobiletin (15 mg/kg).