Table 3 Effects of nobiletin or losartan on cardiac function in 2K-1C rats.

From: Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats

Parameter

Sham

2K-1C

Vehicle

Vehicle

Nobiletin

30 mg/kg

Losartan

10 mg/kg

IVSd (mm)

1.61 ± 0.04

2.00 ± 0.08a

1.76 ± 0.09

1.64 ± 0.13b

IVSs (mm)

2.56 ± 0.05

2.85 ± 0.15

2.90 ± 0.19

2.63 ± 0.14

LVIDd (mm)

8.29 ± 0.02

8.20 ± 0.23

8.04 ± 0.13

8.29 ± 0.13

LVIDs (mm)

4.65 ± 0.07

5.33 ± 0.17a

4.39 ± 0.23b

4.65 ± 0.14b

LVPWd (mm)

1.73 ± 0.05

2.30 ± 0.02a

2.08 ± 0.11

1.64 ± 0.14b

LVPWs (mm)

2.66 ± 0.08

3.10 ± 0.23

2.98 ± 0.16

2.57 ± 0.25b

EDV (mL)

1.26 ± 0.08

1.16 ± 0.09

1.13 ± 0.05

1.23 ± 0.07

ESV (mL)

0.25 ± 0.02

0.36 ± 0.04a

0.22 ± 0.03b

0.25 ± 0.02b

EF (%)

79.73 ± 0.73

69.28 ± 0.97a

80.82 ± 1.97b

79.78 ± 0.81b

SV (mL)

1.00 ± 0.06

0.805 ± 0.05a

0.91 ± 0.03

0.99 ± 0.03b

FS (%)

43.75 ± 0.85

34.65 ± 0.58a

45.24 ± 2.35b

42.65 ± 0.68b

  1. The data are expressed as the means ± SEMs.
  2. IVSd interventricular septum thickness at diastole, IVSs interventricular septum thickness at systole, LVIDd left ventricular internal dimension at end-diastole, LVIDs left ventricular internal dimension at end-systole, LVPWd left ventricular posterior wall thickness at diastole, LVPWs left ventricular posterior wall thickness at systole, EDV end-diastolic volume, ESV end-systolic volume, SV stroke volume, EF ejection fraction, FS fractional shortening, 2K-1C two-kidney, one-clip.
  3. aP < 0.05 vs. sham.
  4. bP < 0.05 vs. 2K-1C.
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