Table 4 Effects of nobiletin or losartan on kidney function in 2K-1C rats.

From: Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats

Parameter

Sham

2K-1C

Vehicle

Vehicle

Nobiletin

30 mg/kg

Losartan

10 mg/kg

Urine creatinine (mg/dL)

137.42 ± 15.82

67.02 ± 17.26a

116.68 ± 15.67

116.88 ± 12.81

Urine flow (mL/min)

0.02 ± 0.003

0.015 ± 0.002

0.01 ± 0.001

0.02 ± 0.004

Serum creatinine (mg/dL)

0.97 ± 0.11

1.38 ± 0.09a

0.81 ± 0.48b

0.81 ± 0.08b

eGFR (mL/min)

2.95 ± 0.32

0.91 ± 0.35a

1.82 ± 0.34b

2.47 ± 0.33b

Albuminuria (mg/dL)

18.81 ± 3.5

187.59 ± 11.82a

117.61 ± 2.08a,b

86.06 ± 9.33a,b

Albumin/creatinine ratio

0.14 ± 0.03

4.58 ± 1.48a

1.26 ± 0.17b

0.88 ± 0.09b

  1. The data are expressed as the means ± SEMs.
  2. 2K-1C two-kidney, one-clip, eGFR estimated glomerular filtration rate.
  3. aP < 0.05 vs. sham.
  4. bP < 0.05 vs. 2K-1C.
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