Scheme 1 | Scientific Reports

Scheme 1

From: Design, synthesis and evaluation of novel tetrahydropyridothienopyrimidin-ureas as cytotoxic and anti-angiogenic agents

Scheme 1The alternative text for this image may have been generated using AI.

Reagents and conditions: (a) K2CO3, DMF, 80 °C, 5 h; (b) sulfur, ethylcyanoacetate, morpholine, EtOH, Reflux, 3 h; (c) Formamidine acetate, DMF, 100 °C, 16 h; (d) POCl3, DBU, 50 °C, 7 h; (e) CS2, Na2CO3, EtOH, Reflux, 8 h; (f) phenylisocyanate derivatives, DIPEA, DCM (dry), r.t., 5 h; (g) DBU, EtOH, 50 °C, 5 h.

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