Table 2 In vitro antiproliferative effects (IC50, µM) of 11b, 11h, 11l, 11m, 11n against MCF-7 and MRC5 cell linesa.

From: Design, synthesis and evaluation of novel tetrahydropyridothienopyrimidin-ureas as cytotoxic and anti-angiogenic agents

Compound

MRC5

MCF7

SI b

11b

32.07 ± 0.92

8.22 ± 0.09

3.9

11h

41.21 ± 0.45

8.52 ± 0.02

4.8

11l

24.82 ± 0.36

2.80 ± 0.03

8.8

11m

33.25 ± 0.44

3.35 ± 0.01

9.9

11n

38.10 ± 0.81

2.67 ± 0.21

14.2

  1. aValues were the means of three replicates ± standard deviation (SD).
  2. bSI = Selectivity Index = IC50 value normal cell/IC50 value cancer cell.
Back to article page