Table 1 Characteristics of IgA nephropathy patients by renal ICR tertiles at biopsy.
Variables | Overall (n = 337) | Renal ICR | P | ||
|---|---|---|---|---|---|
Group 1 1st tertile (n = 112) | Group 2 2nd tertile (n = 113) | Group 3 3rd tertile (n = 112) | |||
Baseline | |||||
Renal ICR levels | 2.11 (1.21–4.27) | < 1.56 | 1.56–3.04 | > 3.04 | < 0.001 |
Age (years) | 35.0 (26.5–44.0) | 33.0 (28.0–46.0) | 32.0 (23.0–45.5) | 36.0 (29.2–43.0) | 0.075 |
Sex (men, %) | 193 (57.3) | 57 (50.9) | 75 (66.4) | 61 (54.5) | 0.049 |
MAP (mmHg) | 99.0 (93.0–107.1) | 99.5 (93.0–105.5) | 95.6 (90.3–103.8) | 104.5 (97.0–112.6) | < 0.001 |
eGFR (mL/min/1.73 m2) | 83.2 (58.2–108.2) | 91.3 (55.9–111.6) | 78.7 (60.8–108.3) | 80.9 (50.2–105.3) | 0.157 |
Proteinuria (g/24 h) | 1.48 (0.83–2.77) | 1.22 (0.77–2.15) | 1.42 (0.92–2.55) | 1.88 (0.81–3.15) | 0.006 |
Oxford classification | |||||
M1, n (%) | 145 (43.0) | 32 (28.6) | 48 (42.5) | 65 (58.0) | < 0.001 |
E1, n (%) | 100 (29.7) | 30 (26.8) | 34 (30.1) | 36 (32.1) | 0.676 |
S1, n (%) | 194 (57.6) | 40 (35.7) | 83 (73.5) | 71 (63.4) | < 0.001 |
T1, n (%) | 112 (33.2) | 22 (19.6) | 50 (44.2) | 40 (35.7) | < 0.001 |
T2, n (%) | 73 (21.7) | 16 (14.3) | 29 (25.7) | 28 (25.0) | 0.067 |
C1, n (%) | 145 (43.0) | 28 (25.0) | 65 (57.5) | 52 (46.4) | < 0.001 |
C2, n (%) | 22 (6.5) | 5 (4.5) | 7 (6.2) | 10 (8.9) | 0.395 |
Follow-up | |||||
Follow-up interval (months) | 42.96 (37.31–61.35) | 47.60 (37.33–71.88) | 42.10 (38.03–58.00) | 45.23 (37.25–59.36) | 0.184 |
Treated with steroids/other immunosuppressive agents, n (%) | 181 (53.7) | 54 (48.2) | 52 (46.0) | 75 (67.0) | 0.003 |
Outcome | |||||
Composite end point, n (%) | 102 (30.3) | 21 (18.8) | 29 (25.7) | 52 (46.4) | < 0.001 |
ESRD, n (%) | 20 (5.9) | 5 (4.5) | 2 (1.8) | 13 (11.6) | 0.006 |
