Table 3 Logistic regression analysis to identify whether NLR and PLR are associated with depressive symptoms.

From: Higher neutrophil–lymphocyte ratio is associated with depressive symptoms in Japanese general male population

 

Males

Females

aOR (95%CI)

P-value

aOR (95%CI)

P-value

NLR, per 1 increase

1.570 (1.120–2.220)

0.009*

0.871 (0.652–1.160)

0.349

PLR, per 1 increase

1.000 (0.994–1.010)

0.899

1.000 (0.997–10.10)

0.520

Age

 < 45

Reference

 

Reference

 

45 ≤ , < 65

0.546 (0.285, 1.050)

0.069

0.668 (0.392, 1.140)

0.137

65 ≤ , < 75

0.763 (0.344, 1.690)

0.504

0.912 (0.463, 1.800)

0.790

75 ≤ 

0.359 (0.111, 1.160)

0.087

0.734 (0.289, 1.860)

0.516

BMI

18.5 ≤ , < 25

Reference

 

Reference

 

 < 18.5

0.355 (0.043, 2.920)

0.335

1.470 (0.780, 2.790)

0.233

25 ≤ , < 30

0.674 (0.352, 1.290)

0.235

1.400 (0.812, 2.420)

0.225

30 ≤ 

0.837 (0.279, 2.510)

0.751

0.822 (0.258, 2.620)

0.741

AST, per 1 U/L increase

–

 

0.951 (0.900–1.010)

0.077

ALT, per 1 U/L increase

–

 

1.020 (0.986–1.050)

0.247

Hypertension

1.060 (0.523–2.130)

0.881

1.340 (0.766–2.340)

0.305

DM

1.030 (0.355–2.960)

0.964

0.565 (0.151–2.110)

0.397

Dyslipidemia

1.080 (0.446–2.600)

0.871

1.360 (0.706–2.630)

0.357

CAD

–

 

0.476 (0.056–4.040)

0.496

Stroke

1.000 (1.000–1.000)

0.551

1.000 (1.000–1.000)

0.596

Alcohol drinker

0.548 (0.322–0.930)

0.026*

  
  1. *P < 0.05. As none of the VIF values were up to 10, there was no collinearity in the model. AUC values for males and females were 0.675 and 0.603, respectively. Hosmer–Lemeshow test: P = 0.36, which means that the fitness of this model was good.
  2. aOR adjusted odds ratio, ALT alanine transferase, AST aspartate transferase, BMI body mass index, CAD coronary artery disease, DM diabetes mellitus, NLR neutrophil–lymphocyte ratio, PLR platelet-lymphocyte ratio.
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