Table 1 Association analysis of rs146589465-G.

From: Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62

A1a

A2a

Freq. A1a [%]

Phenotype

N cases

N controls

P-value

ORa (A1)

95% CI

G

C

0.12

Cholangiocarcinoma

353

233,169

1.3 × 10–3

6.56

(2.085–20.64)

   

Pituitary adenoma

422

303,642

3.9 × 10–3

5.22

(1.699–16.03)

   

Hepatocellular carcinoma

280

301,578

2.9 × 10–2

4.95

(1.178–20.80)

  1. Shown are associations for rs146589465-G in the Icelandic cohort that reached a threshold of P-value less than 5.0 × 10–2. The variant results in coding change p.D522E in ATG7.
  2. aA1 and A2 stand for the two alleles tested for the marker. Odds-ratio (OR) and population allele frequency (Freq. A1) are provided for allele A1.
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