Figure 3
From: Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-β2
A total of 14 genes were linked together via biological pathways and/or functions that are directly related to glaucoma or TGFβ signalling. The STRING database on the Cytoscape software was used to visualise interactions between upregulated (red) and downregulated (green) genes, with a fold change > 2 and p value < 0.05. Candidate genes were calculated using MCODE to create clusters followed by the ClueGo/CluePedia and KEGGscape plugins, which visualises the important biological processes and pathways for clusters of genes in a functional grouped network. The results were graphed to depict the following: solid lines indicate a relationship between the identified gene and nominated biological functions while dotted lines connect genes to signalling pathways known to play a role in POAG.
