Figure 5 | Scientific Reports

Figure 5

From: PSPC1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates RNA processing of ESR1 and SCFD2

Figure 5

SCFD2-targeted siRNA suppresses in vivo tumor growth of tamoxifen-resistant breast cancer cells. (A) Representative images of xenografted mice at the day of sacrifice. (B) Effect of siSCFD2 #1 on growth of OHTR-derived xenograft tumors in athymic mice. Indicated siRNAs were intratumorally injected into xenografted mice twice a week. Tumor volumes are presented as mean ± SEM (n = 4). (C–E) Expression of SCFD2 (C), DDIAS (D), and MYBL1 (E) mRNAs in OHTR-derived tumors. Relative expression levels of these mRNAs were normalized to GAPDH mRNA level in each sample and presented as mean fold ± SEM compared with siControl (n = 4). *P < 0.05; ***P < 0.001, Student’s t-test. (F) Schematic image for a potential role of PSPC1/PSF/SCFD2 axis in ER-positive breast cancer.

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