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Figure 1

From: Vagus nerve stimulation does not improve recovery of forelimb motor or somatosensory function in a model of neuropathic pain

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VNS paired with tactile rehabilitation fails to improve forelimb withdrawal thresholds. Radial nerve injury produces lasting allodynia in the forelimb, as demonstrated by sustained reductions in forelimb withdrawal thresholds. VNS paired with tactile therapy, consisting of mechanical stimulation of either the dorsal (Dorsal Tactile + VNS, n = 8) or ventral (Ventral Tactile + VNS, n = 7) surface of the forepaw, fails to improve withdrawal thresholds compared to tactile therapy without VNS (Ventral Tactile, n = 6) or no therapy (Untreated, n = 8). Data presented as mean ± SEM. *** denotes p < 0.001 at the indicated timepoints; n.s. denotes not significant group effect.

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