Figure 5
From: Telomere-to-telomere human DNA replication timing profiles
Replication timing (RT) dynamics are not substantially different in centromeric regions than in the rest of the genome. (a, c) The distance between RT peaks was used as a metric of inter-origin distance. Inter-origin distances were slightly larger in centromeric regions (green, a) and α-satellite higher-origin repeats (blue, c), relative to the rest of the genome (gray). (b, d) RT profile slope was used as a proxy for replication fork speed. For each peak, the ascending and descending slopes are averaged. RT slopes were slightly shallower in centromeric regions (green, b) and α-satellite higher-origin repeats (blue, d), relative to the rest of the genome (gray). RT values are for the lymphoblastoid cell line GM12878.
