Figure 2
From: Curcumin and metformin synergistically modulate peripheral and central immune mechanisms of pain
Cytotoxicity profile of LPS-stimulated RAW 264.7 macrophage (A) and BV-2 microglial (B) cells with or without treatment of curcumin (CUR), metformin (MET), or their combination. RAW 264.7 macrophages were treated with 0.625–5 µM of CUR, 0.125–1 mM of MET, or their combination at a 1:200 CUR: MET ratio for 12 h, whereas BV-2 cells were treated with 1.25–10 µM of CUR, 0.125–1 mM of MET or their combination at a 1:100 ratio of CUR: MET for 24 h. The cell viability was determined by MTT assay and expressed as a percentage of the control. Experimental data are presented as mean ± SD, n = 3 independent experiments.
