Figure 9
From: Curcumin and metformin synergistically modulate peripheral and central immune mechanisms of pain
Effects of curcumin and metformin alone or in combination on the general behavior of naïve mice. Behavioral measures were recorded for 24 h post-treatment using LABORAS. (A,B) Time spent on locomotion (A) and frequency of its occurrence (B). (C,D) Time spent on climbing (C) and frequency of its occurrence (D). (E,F) Time spend on rearing behavior (E) and frequency of its occurrence (F). (G,H) Time spent on immobility (G) and frequency of its occurrence (H). (I) Distance traveled by mouse in the cage. (J) Average speed in locomotion. Data are presented as mean ± S.E.M (n = 10 mice/group). Behavioral data were analyzed over 2 h intervals during 24 h test sessions.
