Figure 3

Results of molecular docking. (a) Binding mode of (R)-20d to PI3K δ. (b) Binding mode of (S)-18d to PI3K δ. (c) Binding mode of (R)-19d to PI3K δ. (d) Binding mode of (S)-20d to PI3K γ. (e) Binding mode of Leniolisib to PI3K δ. (f) Binding mode of 2-amino-4-methyl-8-(1-methylethyl)-6-(1H-pyrazol-4-yl)pteridin-7(8H)-one to PI3K γ.