Table 2 Up- and downregulated pathways in the luseogliflozin-treated group.

From: Luseogliflozin preserves the pancreatic beta-cell mass and function in db/db mice by improving mitochondrial function

 

Changed genes

Total genes

Z-score

P-value

Gene symbol

Upregulated pathways

Fatty acid biosynthesis WP336_71737

2

22

4.91

0.01

Pcx, Hadh

IL7 signaling pathway WP297_69128

2

44

3.20

0.04

Ccna2, Ccnd2

Tryptophan metabolism WP79_73389

2

44

3.20

0.04

Hadh, Maob

Glycolysis and gluconeogenesis WP157_69361

2

47

3.06

0.04

Pcx, Slc2a2

Downregulated pathways

Dopaminergic neurogenesis WP1498_60839

3

29

3.72

0.01

Aldh1a1, Shh, Th

Endochondral ossification WP1270_72216

4

62

3.01

0.02

Enpp1, Ctsl, Adamts5, Plat

Glucocorticoid and mineralocorticoid metabolism WP495_71740

2

13

3.93

0.02

Hsd11b1, Cyp17a1

Retinol metabolism WP1259_71742

3

38

3.06

0.03

Aldh1a, Cd36, Bcmo1

Biogenic amine synthesis WP522_69135

2

15

3.59

0.03

Ache, Th

Blood clotting cascade WP460_71727

2

20

2.97

0.04

Vwf, Plat

  1. P values were determined using two-tailed Fisher’s exact tests.
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