Figure 1 | Scientific Reports

Figure 1

From: Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19)

Figure 1

Summary of potential resveratrol effects on virus and host. 1. Inhibits Spike protein to ACE2 binding4,5. 2. Inhibits transcription of viral proteases (Mpro and PLpro)6,7,8,9. 3. Inhibits RNA-dependent RNA polymerase10. 4. Inhibits proinflammatory cytokines11,12,13. 5. Inhibits platelet aggregation14,15. 6. Activates endothelial Nitric Oxide (antiviral and vasoprotective)16,17,18. 7. Inhibits proinflammatory NF-kB19. 8. Inhibits proinflammatory Th-17 T-cells20. 9. Stimulates the production of glutathione in lung epithelium cells21,22,23.

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