Table 3 Median concordance index (CI) values for cross-validation (CV) and external validation for FFDM prediction in MRI, CT, and joint MRI + CT. Values in parenthesis represent the 95% confidence interval.
Modality | Feature level | CV training CI | CV validation CI | Signature | Final training CI | External validation CI |
|---|---|---|---|---|---|---|
MRI | All | 0.79 | 0.60 | MR_log_stat_median | 0.69 (0.56–0.81) | 0.54 (0.36–0.69) |
MFO | 0.77 | 0.60 | MR_stat_median | 0.68 (0.54–0.82) | 0.52 (0.34–0.68) | |
SOT | 0.75 | 0.59 | MR_ ngl_dc_var_d1_a0_0_3d_fbn_n32 MR_ szm_sze_3d_fbn_n32 MR_cm_clust_prom_d1_3d_v_mrg_fbn_n32 | 0.70 (0.58–0.82) | 0.57 (0.40–0.74) | |
LoG | 0.75 | 0.65 | MR_log_stat_median MR_log_stat_iqr MR_log_ih_entropy_fbn_n32 | 0.69 (0.56–0.82) | 0.57 (0.39–0.73) | |
CT | All | 0.74 | 0.46 | No feature selected | – | – |
MFO | 0.73 | 0.47 | CT_morph_volume | 0.62 (0.50–0.75) | 0.58 (0.42–0.73) | |
SOT | 0.70 | 0.51 | CT_szm_zsnu_3d_fbn_n32 | 0.64 (0.49–0.80) | 0.69 (0.51–0.81) | |
LoG | 0.70 | 0.52 | CT_log_stat_energy | 0.65 (0.53–0.76) | 0.63 (0.46–0.77) | |
Joint MRI + CT | MRI_All + CT_All | – | – | MR_log_stat_median | 0.69 [0.56–0.81] | 0.54 (0.36–0.69) |
MRI_MFO + CT_MFO | – | – | MR_stat_median CT_morph_volume | 0.70 [0.55–0.81] | 0.55 (0.37–0.70) | |
MRI_SOT + CT_SOT | – | – | MR_ ngl_dc_var_d1_a0_0_3d_fbn_n32 MR_ szm_sze_3d_fbn_n32 MR_cm_clust_prom_d1_3d_v_mrg_fbn_n32 CT_szm_zsnu_3d_fbn_n32 | 0.73 (0.61–0.84) | 0.62 (0.45–0.79) | |
MRI_LoG + CT_LoG | – | – | MR_log_stat_median MR_log_stat_iqr MR_log_ih_entropy_fbn_n32 CT_log_stat_energy | 0.72 (0.59–0.85) | 0.59 (0.41–0.75) |
