Figure 1 | Scientific Reports

Figure 1

From: Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition

Figure 1

Time course of reflexive pain responses in mice subjected to reserpine-induced myalgia and intramuscular acid saline solution injection. The RIM6 mouse model shows longer-lasting reflexive pain responses than either RIM3 or RIM4 since only RIM6 animals showed significant thermal hyperalgesia (A) and mechanical hypersensitivity (B) up to 6 weeks postinduction. The ASI mouse model shows long-lasting thermal hyperalgesia (C) and mechanical hypersensitivity (D) up to 5 weeks postinduction. Each point and vertical line represent the mean ± standard error of the mean (n = 9–12 per group). a–d: Groups not sharing a letter are significantly different, p < 0.05 according to post hoc test; ***p < 0.0001, **p < 0.01, *p < 0.05 significant decrease versus ASI-Control, by post hoc tests.

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