Figure 2 | Scientific Reports

Figure 2

From: Elevated expression of TLR2 and its correlation with disease activity and clinical manifestations in adult-onset Still’s disease

Figure 2

(A) Representative flow cytometric histograms of stained cells presenting toll-like receptor (TLR) from peripheral blood of one patient with adult-onset Still’s disease (AOSD) and a healthy control (HC) are shown. (B) Flow cytometric results of the percentage of surface-stained cells presenting TLR1, TLR2, TLR4, TLR7, and TLR9 in patients with AOSD and HC. Results were obtained from 20 patients with AOSD and 15 HCs. The bar with horizontal line indicates the mean value with standard deviation for each group. The p-value was determined using the Mann–Whitney U-test. Significantly higher mean intensity of stained cells presenting TLR2 was observed in patients with AOSD than in HC (p < 0.001). A significantly higher intensity of cells presenting TLR7 from whole blood was seen in patients with AOSD than in HC (p = 0.006). However, there was no significant difference in the intensity of cells presenting TLR1, TLR4, or TLR9 between patients with AOSD and HCs.

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