Table 1 Clinical characteristics of patients.

From: Elevated expression of TLR2 and its correlation with disease activity and clinical manifestations in adult-onset Still’s disease

 

AOSD (n = 20)

HC (n = 15)

p-value

Age (years)

50.1 ± 13.6

43.2 ± 7.8

0.069

Gender (F/M)

13/7

7/8

0.321

Systemic manifestation/chronic articular manifestation

15/5

  

Fever

10 (50)

  

Sore throat

4 (20)

  

Skin rash

12 (60)

  

Lymphadenopathy

3 (15)

  

Splenomegaly

2 (10)

  

Hepatomegaly

2 (10)

  

Pericarditis

0 (0)

  

Arthritis

6 (30)

  

Hemoglobin, g/dL

12.7 ± 1.7

  

Leukocytes, /μL

9,515 ± 4,570

  

Neutrophils, /μL

7,306 ± 4,447

  

Platelets, × 103/μL

287.7 ± 137.0

  

Ferritin, ng/mL

2,137.6 ± 4,512.0

  

ESR, mm/h

37.1 ± 31.8

  

CRP, mg/dL

5.63 ± 9.06

  

AST/ALT, mg/dL

39.7 ± 39.1/34.8 ± 27.4

  

Bilirubin, mg/dL

0.55 ± 0.31

  

Albumin, g/dL

4.2 ± 0.6

  

Systemic score

2.5 ± 1.9

  

IL-1β, pg/mL

1.86 ± 5.99

0.00 ± 0.00

0.214

IL-6, pg/mL

9.56 ± 15.1

0.00 ± 0.00

0.012

IL-18, ng/mL

7.47 ± 6.44

0.44 ± 0.34

 < 0.001

TNF-α, pg/mL

4.54 ± 7.65

0.42 ± 1.25

0.086

  1. AOSD, adult-onset Still’s disease; HC, healthy control; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AST, aspartate transaminase; ALT, alanine transaminase; IL, interleukin; TNF, tumor necrosis factor. All values are presented as numbers (with percentages) or means ± standard deviations. The systemic scoring system of Pouchot et al.40 assigns a score from 0 to 12 with 1 point for each of the following manifestations: fever, typical rash, pleuritis, pneumonia, pericarditis, hepatomegaly or abnormal liver function test data, splenomegaly, lymphadenopathy, leukocytosis ≥ 15,000/mm2, sore throat, myalgia, and abdominal pain. These data were assessed using a Mann–Whitney U test or Fisher’s Exact test.
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