Table 2 Correlation between each Toll-like receptor (TLR) level and levels of disease activity markers in adult onset Still’s disease.

From: Elevated expression of TLR2 and its correlation with disease activity and clinical manifestations in adult-onset Still’s disease

Disease activity markers

Correlation coefficient, r (p-value)

TLR1

TLR2

TLR4

TLR7

TLR9

Systemic score

0.440 (0.052)

0.446 (0.049)

0.178 (0.452)

− 0.057 (0.811)

0.379 (0.099)

Leukocyte

− 0.200 (0.397)

− 0.261 (0.265)

− 0.342 (0.140)

− 0.265 (0.260)

− 0.286 (0.222)

Neutrophil

− 0.280 (0.232)

− 0.247 (0.295)

− 0.349 (0.132)

− 0.211 (0.373)

− 0.195 (0.409)

Hemoglobin

− 0.178 (0.453)

− 0.294 (0.208)

− 0.001 (0.996)

0.091 (0.704)

− 0.185 (0.435)

Platelet

− 0.027 (0.911)

− 0.079 (0.741)

− 0.026 (0.914)

0.140 (0.556)

− 0.180 (0.448)

ESR

− 0.058 (0.807)

− 0.013 (0.957)

− 0.194 (0.413)

− 0.194 (0.414)

− 0.107 (0.653)

CRP

− 0.015 (0.950)

− 0.052 (0.827)

− 0.138 (0.562)

− 0.172 (0.468)

− 0.056 (0.814)

Ferritin

0.804 (< 0.001)

0.829 (< 0.001)

0.547 (0.015)

0.141 (0.553)

0.798 (< 0.001)

LDH

0.716 (< 0.001)

0.728 (< 0.001)

0.465 (0.039)

0.203 (0.391)

0.686 (0.001)

Albumin

− 0.096 (0.688)

− 0.140 (0.557)

0.142 (0.549)

0.232 (0.324)

− 0.079 (0.740)

Bilirubin

0.029 (0.903)

− 0.049 (0.839)

0.038 (0.874)

0.060 (0.801)

0.056 (0.816)

AST

− 0.071 (0.765)

− 0.072 (0.762)

− 0.273 (0.244)

− 0.374 (0.104)

− 0.164 (0.491)

ALT

− 0.154 (0.516)

− 0.260 (0.269)

− 0.297 (0.204)

− 0.245 (0.298)

− 0.299 (0.200)

IL-1β

0.309 (0.071)

0.380 (0.025)

0.387 (0.022)

0.070 (0.689)

0.148 (0.395)

IL-6

0.140 (0.422)

0.474 (0.004)

0.126 (0.470)

0.267 (0.121)

0.180 (0.301)

IL-18

0.174 (0.317)

0.606 (< 0.001)

0.112 (0.523)

0.385 (0.022)

0.213 (0.219)

TNF-α

0.130 (0.457)

0.318 (0.063)

− 0.028 (0.875)

0.070 (0.689)

− 0.023 (0.895)

TLR1

 

0.928 (< 0.001)

0.806 (< 0.001)

0.584 (< 0.001)

0.905 (< 0.001)

TLR2

0.928 (< 0.001)

 

0.838 (< 0.001)

0.588 (< 0.001)

0.932 (< 0.001)

TLR4

0.806 (< 0.001)

0.838 (< 0.001)

 

0.669 (< 0.001)

0.813 (< 0.001)

TLR7

0.584 (< 0.001)

0.588 (< 0.001)

0.669 (< 0.001)

 

0.614 (< 0.001)

  1. ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; LDH, lactate dehydrogenase; AST, aspartate transaminase; ALT, alanine transaminase; IL, interleukin; TNF, tumor necrosis factor. Spearman’s correlation coefficients were calculated. The systemic scoring system of Pouchot et al.40 assigns a score from 0 to 12 with 1 point for each of the following manifestations: fever, typical rash, pleuritis, pneumonia, pericarditis, hepatomegaly or abnormal liver function test data, splenomegaly, lymphadenopathy, leukocytosis ≥ 15,000/mm2, sore throat, myalgia, and abdominal pain. These data were assessed using a Spearman’s correlation test.
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