Figure 5
From: Microliter-scale reaction arrays for economical high-throughput experimentation in radiochemistry
Influence of reaction parameters on the performance of the microdroplet radiosynthesis of [18F]PBR06. For each parameter, influence on fluorination efficiency, collection efficiency, and crude RCY are plotted individually. (A) Effect of precursor concentration (and solvent). Reaction volume: 8 µL. Base amount: 240 nmol. Reaction time: 5 min. Reaction temperature 100 °C. (B) Effect of amount of base (and solvent). Precursor amount: 160 nmol. Reaction volume: 8 µL. Reaction temperature: 100 °C. Reaction time: 5 min. (C) Effect of temperature (and solvent). Precursor amount: 160 nmol. Reaction volume: 8 µL. Base amount: 240 nmol. Reaction time: 5 min. (D) Effect of reaction time (and solvent). Precursor amount: 160 nmol. Reaction volume: 8 µL. Base amount: 240 nmol. Reaction temperature: 100 °C. (E) Effect of the base type. Precursor amount: 160 nmol. Reaction volume: 8 µL. Base amount: 240 nmol. Reaction temperature: 100 °C. Reaction time: 0.5 min.
