Figure 9 | Scientific Reports

Figure 9

From: Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2

Figure 9

Tsk mouse anomalous aqueous humor TGFβ2. (a) Aqueous humor TGFβ2 levels in Tsk (red) and WT (black) mice aged 6–9 months (solid) and 12–16 months (striped) (n = 9–10 per group; based on duplicate assays, ELISA). Comparisons: * WT mice aged 6–9 m and 12–15 m (p = 0.006); ** Tsk mice aged 6–9 m and 12–15 m (p = 0.002); ϕϕ WT and Tsk mice aged 6–9 m (p = 0.07); ϕ WT and Tsk mice aged 12–15 m (p = 0.017). (b) Aqueous humor TGFβ2 activity in Tsk and WT mice (*p = 1E−11; Mink lung epithelial cell-based bioassay) (*p = 1E−11). Bars: mean; Error bars: standard error of mean.

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