Table 5 Receiver operating characteristics (ROC) analysis of the comparison groups in the discovery and validation datasets.
From: Predictive blood biomarkers of sheep pregnancy and litter size
ROC | ||||||
|---|---|---|---|---|---|---|
Discovery phase | Validation phase | |||||
Day − 7 | Day 0 | Day 35 | Day 50 | Day 70 | Day 50 | |
CNT vs PRG | NA | NA | NA | Methanol, l-carnitine, d-glucose, l-arginine, urea | Urea, glycine | Methanol, l-carnitine, d-glucose, l-arginine, urea |
NA | NA | NA | AU-ROC = 0.76 p < 0.10 | AU-ROC = 0.98 p < 0.001 | AU-ROC = 0.90 p < 0.05 | |
CNT vs MLP | NA | l-Ornithine, choline | Acetone, l-ornithine, C0, total dimethylarginine | Methanol, l-carnitine, d-glucose, l-arginine, urea | Choline, urea, l-arginine, glycine | Methanol, l-carnitine, d-glucose, l-arginine, urea |
NA | AU-ROC = 0.79 p < 0.05 | AU-ROC = 0.73 p < 0.05 | AU-ROC = 0.76 p < 0.05 | AU-ROC = 0.97 p < 0.01 | AU-ROC = 0.93 p < 0.001 | |
SNG vs TRP | Choline, l-carnitine, l-phenylalanine | C4, l-threonine, trans-hydroxyproline | l-Acetylcarnitine, l-carnitine, trans-hydroxyproline | Methionine, l-carnitine | Choline, d-glucose, l-phenylalanine | Methionine, l-carnitine |
AU-ROC = 0.80 p < 0.05 | AU-ROC = 0.74 p < 0.05 | AU-ROC = 0.76 p < 0.10 | AU-ROC = 0.78 p < 0.05 | AU-ROC = 0.81 p < 0.05 | AU-ROC = 0.84 p < 0.001 | |
TWN vs TRP | Hypoxanthine, l-phenylalanine, choline, l-carnitine, creatinine | Serotonin, C3 | Hypoxanthine, trans-hydroxyproline, kynurenine | Isobutyric acid, l-lactic acid, l-carnitine, valine, tyrosine, methanol | Hypoxanthine, l-phenylalanine, l-carnitine, isobutyric acid | Isobutyric acid, l-lactic acid, l-carnitine, valine, tyrosine, methanol |
AU-ROC = 0.77 p < 0.10 | AU-ROC = 0.74 p < 0.05 | AU-ROC = 0.75 p < 0.05 | AU-ROC = 0.66 p < 0.10 | AU-ROC = 0.77 p < 0.05 | AU-ROC = 0.81 p < 0.05 | |
