Table 1 Participant baseline demographics by disease stage.

From: Alterations in metal homeostasis occur prior to canonical markers in Huntington disease

 

Control (n = 12)

Pre-manifest (n = 16)

Manifest (n = 16)

Late manifest (n = 16)

Age

47.75 ± 10.81a

39.125 ± 9.78b

47.0625 ± 7.34a

57.6875 ± 8.74c

Sex (M,F)

7,5

8,8

7,9

9,7

CAG

19.75 ± 3.89a

42.4375 ± 1.46b

43.75 ± 1.77b

43.8125 ± 1.87b

TFC

12.92 ± 0.29a

12.625 ± 0.62a

10.25 ± 3.34b

5.0625 ± 4.25c

SDMT

55.67 ± 10.05a

52.75 ± 15.93a

34.25 ± 13.89b

21.33 ± 16.09c

SWR

107.75 ± 17.51a

84.1875 ± 28.03b

62.4375 ± 19.17c

43.82 ± 29.10d

TMS

1.42 ± 3.70a

6.3125 ± 8.93b

29.0625 ± 22.39c

58.01 ± 29.97d

cUHDRS

17.71 ± 1.72a

15.80 ± 2.73a

10.30 ± 4.99a

5.80 ± 6.76b

  1. Differences in baseline demographic variables were identified using a 1-way ANOVA with post-hoc testing after determination of a significant main effect (p < 0.05). Participant age is reported in years as well as the proportion of males to females (M,F). The number of trinucleotide repeats (CAG) as well as performance on total functional capacity (TFC), symbol digit modality test (SDMT), stroop word reading (SWR), total motor score (TMS) and the compositive United Huntington Disease Rating Scale (cUHDRS) scores are reported here as mean ± S.D and values that do not significantly differ share a superscript.