Table 2 The number of specific splice events and associated opposing events.

AS type	nUp	nDown	propUp	p value	Q value
A3 gain (paired with A3 loss)	28	13	0.68 (0.52–0.82)	0.03	0.13
A5 gain (paired with A5 loss)	27	15	0.64 (0.48–0.78)	0.09	0.24
ATSS gain (paired with ATSS loss)	33	54	0.38 (0.28–0.49)	0.03	0.13
ATTS gain (paired with ATTS loss)	28	40	0.41 (0.29–0.54)	0.18	0.36
ES (paired with EI)	30	21	0.59 (0.44–0.72)	0.26	0.42
IR gain (paired with IR loss)	27	27	0.50 (0.36–0.64)	1.00	1.00
MEE gain (paired with MEE loss)	0	1	0.00 (0.00–0.98)	1.00	1.00
MES (paired with MEI)	11	17	0.39 (0.22–0.59)	0.34	0.46

The number of genes with a specific AS type is obtained by comparing non-survivors versus survivors. For examlpe, there were 28 genes filtered by significance test with A3 gain and 13 genes with significant A3 loss.
nUp number of up regulation, nDown number of downregulation, propUp proportion of upregulation, AS alternative splicing, IR intron retention, A5 alternative 5′ donor site (changes in the 5′end of the upstream exon) , A3 Alternative 3′ acceptor site (changes in the 3′end of the downstream exon), ATSS alternative transcription start site, ATTS alternative transcription termination site, ES exon skipping, MES multiple exon skipping, skipping of > 1 consecutive exons, MEE mutually exclusive exons.

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