Figure 8

Diagnostic features of KCTD family genes in patients with LUAD. (A) ROC analysis showed that KCTDs (KCTD12, KCTD10, KCTD16, KCTD5) can clearly distinguish LUAD from normal samples. Three prediction models, namely Model 1 (including only target genes), Model 2 (including target genes and clinicopathological parameters) and Model 3 (excluding target genes). (B) KCTD12. AUC_{Model 1} = 0.924, P < 0.001; AUC_{Model 2} = 0.926, P < 0.001; AUC_{Model 3} = 0.585, P < 0.05. (C) KCTD10. AUC_{Model 1} = 0.916, P < 0.001; AUC_{Model 2} = 0.916, P < 0.001; AUC_{Model 3} = 0.585, P < 0.05. (D) KCTD16. AUC_{Model 1} = 0.892, P < 0.001; AUC_{Model 2} = 0.830, P < 0.001; AUC_{Model 3} = 0.585, P < 0.05. (E) KCTD5. AUC_{Model 1} = 0.845, P < 0.001; AUC_{Model 2} = 0.851, P < 0.001; AUC_{Model 3} = 0.585, P < 0.05. The AUC of Model 1 and Model 2 was close to and significantly larger than Model 3. The red line is KCTD12, the green line is KCTD10, the blue line is KCTD16, and the orange line is KCTD5. The black line is Model 2, the purple line is Model 3.