Figure 6 | Scientific Reports

Figure 6

From: AGE/RAGE axis regulates reversible transition to quiescent states of ALK-rearranged NSCLC and pancreatic cancer cells in monolayer cultures

Figure 6

Aerobic glycolysis was elevated in quiescence-inducible H2228 and A549 cells under GG conditions. (a) MSEA between quiescence-inducible and quiescence-non-inducible A549 cell lines under GG conditions. Altered metabolic pathways were analyzed using the QEA algorithm. The 20 most significantly altered metabolic pathways are shown. (b) Heatmap showing relative abundance of metabolites relating to aerobic glycolysis among H2228, A549, and AsPC-1 cells under GG conditions; n = 3. Color scale (cyan to yellow) indicates relative metabolite concentration. (c) Proliferation of H2228, AsPC-1, and A549 cells under GG and HSS conditions with control IgG (IgG) or anti-receptor for advanced glycation end products (αRAGE) antibodies. Proliferation rates are shown. **p < 0.01. n.s., not significant; n = 3. (d) Proposed regulatory mechanism of cell proliferation in quiescence-inducible cells. GF, growth factor; AGE, advanced glycation end products.

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