Figure 4
From: Anti-HER2 scFv-CCL19-IL7 recombinant protein inhibited gastric tumor growth in vivo
HCI fusion protein mediated autoimmune cell antitumor activity in vivo. (A) FACS analysis revealed the presence of memory associated human cells in NOD/SCID mouse peripheral blood 4 weeks after homoimmune reconstitution. (B) Tumor tissue images of sacrificed mice with different effector cell treatments are shown. (C) After sacrifice, the tumor tissues were obtained and cut into sections for H&E staining. Images of NS (left), trastuzumab (middle) and HCI fusion protein(right)-treated groups of sections are shown, scale bars = 50 μm. (D) Immunofluorescence images showing DC (anti-DEC205 staining, green) and T cell infiltration (anti-CD3 staining, red)in the NS(left), trastuzumab (middle) and HCI fusion protein(right)-treated groups, scale bars = 50 μm.
