Table 1 Baseline characteristics of all patients on day 1.

From: Mitochondrial Sirt3 serves as a biomarker for sepsis diagnosis and mortality prediction

 

Sepsis (n = 35)

Septic shock (n = 16)

ICU control (n = 28)

P value

Sex [male] (%)

21 (60%)

12 (75%)

17 (60.7%)

 

Age (years)

57.88 ± 20.78

64.06 ± 17.02

58.25 ± 20.70

0.587

MAP (mmHg)

81.58 ± 10.94

84.38 ± 6.84

86.36 ± 10.36

0.173

HR (bpm)

89.09 ± 17.836

100.44 ± 14.02

78.18 ± 15.38

 < 0.05

CVP (cmH2O)

6.91 ± 2.17

9.12 ± 2.19

–

 < 0.05

past medical history (n, %)

Hypertension

11 (31.4%)

9 (56.25%)

13 (46.23%)

 

Diabetes

8 (22.9%)

3 (18.75%)

7 (25%)

 

Hyperlipidemia

4 (11.4%)

1 (6.25%)

5 (17.86%)

 

Cardiovascular disease

4 (11.4%)

3 (18.75%)

11 (39.29%)

 

Cerebral infarction

2 (5.7%)

1 (6.25%)

3 (10.71%)

 

Site of infection (n, %)

Pneumonia

7 (20%)

1 (6.25%)

–

 

Peritonitis

12 (34.29%)

8 (50%)

–

 

Central system infection

4 (11.42%)

2 (12.5%)

–

 

Bloodstream infection

5 (14.29%)

2 (12.25%)

–

 

Skin infections

2 (5.7%)

1 (6.25%)

–

 

Others

5 (14.29%)

2 (12.25%)

–

 

SOFA score

9.37 ± 3.34

13.35 ± 2.828

1.57 ± 2.659

 < 0.05

APACHE II score

18 ± 7.68

21.5 ± 7.95

13.5 ± 6.46

 < 0.05

NE (ug/kg/min)

0.049 (0,0.568)

0.798 (0.071,1.15)

–

 < 0.05

Lactate (mmol/L)

1.2 (0.6,2.6)

3.5 (2.1,9.7)

0.6 (0.8,3)

 < 0.05

P(V-A)CO2 (mmHg)

2.9 (1.65,4.6)

3.2 (1.25,4.88)

 

0.828

ScvO2 (%)

74.17 ± 8.14

75.87 ± 10.03

–

0.54

OI

314.58 ± 125.46

268.41 ± 118.83

374.70 ± 132.47

 < 0.05

PCT (ng/ml)

15.34 ± 23.45

16.97 ± 23.65

0.67 ± 1.29

 < 0.05

WBC (109/L)

14.24 ± 7.68

10.68 ± 9.07

11.78 ± 2.55

0.155

TNF-α (mg/L)

17.49 ± 12.84

30.80 ± 15.71

–

 < 0.05

IL-10 (pg/ml)

7.35 (5.175,109.5)

15.6 (7.24,52.3)

–

0.108

IL-6 (pg/ml)

136.49 ± 267.47

446.41 ± 87.45

–

 < 0.05

CTNI (ng/ml)

5.32 ± 21.38

40.64 ± 151.21

0.18 ± 0.02

0.402

NT-proBNP (pg/ml)

6075.47 ± 9225.54

7972.45 ± 10,137.53

893.85 ± 700.20

0.244

Length of ICU stay (days)

8 (3.5,8.75)

12 (8,43)

1 (1,17)

 < 0.05

Length of hospital stay (days)

27 (5,121)

34.5 (3,88)

9 (3,38)

 < 0.05

28-day mortality rate (n,%)

4 (11.42%)

5 (37.5%)

0

 < 0.05

  1. Values are expressed as mean ± standard deviation, or median (interquartile range), or number (percentage). P < 0.05 were considered statistically significant. 
  2. MAP mean arterial pressure, HR heart rate, CVP Central venous pressure, SOFA Score Sequential Organ Failure Assessment Score, APACHE II score Acute Physiology and Chronic Health Evaluation II score, NE Norepinephrine, P(V-A)CO2 central venous-to-arterial carbon dioxide difference, ScvO2 Central venous oxygen saturation, OI oxygenation index, PCT procalcitonin, WBC white blood cell, TNF-α Tumor Necrosis Factor α, IL-10 Interleukin-10, IL-6 Interleukin-6, CTNI cardiac troponin I, NT-proBNP N-terminal (NT)-prohormone Brain natriuretic peptide.
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