Table 2 The AUC and optimal study parameter cutoff points for different indicators of septic shock and their associated diagnostic and efficacy values.

From: Mitochondrial Sirt3 serves as a biomarker for sepsis diagnosis and mortality prediction

 

AUC ± SE

P-value

Cut-off value

Sensitivity (%)

Specificity (%)

Lactate

0.986 ± 0.012

< 0.001

2 (mmol/l)

100%

91.43%

ScvO2

0.567 ± 0.094

0.46

83.5 (%)

31.25%

89.66%

Sirt3

0.690 ± 0.078

 < 0.05

15.33 (pg/ml)

75%

60%

P(V-A)CO2

0.518 ± 0.094

0.84

1.25 (mmHg)

25%

89.66%

Lactate + Sirt3

0.988 ± 0.011

 < 0.001

–

100%

94.29%

Lactate + ScvO2

0.982 ± 0.015

 < 0.001

–

100%

93.1%

  1. ScvO2 Central venous oxygen saturation, P(V-A)CO2 central venous-to-arterial carbon dioxide difference. AUC the area under the ROC curve; Cut-off value the optimal cutoff points for the sample diagnosis of septic shock. P < 0.05 means statistically significant.
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